RU-58841, also known as PSK-3841 or HMR-3841, is a nonsteroidal anti-androgen which was formerly under investigation for potential use as a topical treatment for androgen-dependent conditions including acne, pattern hair loss, and excessive hair growth.
RU-58841 prevents the binding of DHT to the androgen receptor in dermal papilla cells located in the hair follicle. When bound, RU58841 prevents androgen binding but does not activate or deactivate the receptor itself. This action suppresses hair follicle miniaturization by stopping DHT from activating the androgen receptor. In studies it is shown to exert its action locally on the scalp and surrounding hair follicles, but not systemically.
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